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Table 1 Classification of CGD subunits.

From: Chronic Granulomatous Disease; fundamental stages in our understanding of CGD

CGD gene

Genetic Transmission

Frequency (%)

gp91phox (CYBB)

X-linked

65

p47phox (NCF1)

Autosomal recessive

25

p67phox (NCF2)

Autosomal recessive

5

p22phox (CYBA)

Autosomal recessive

5

  1. Mutations can occur in one of four NADPH oxidase subunits which give rise to X-linked or autosomal recessive CGD. The approximate frequencies of case occurrence are shown, with figures extrapolated from Clark et al. [35] and Dineaur et al.[38].
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Medical Immunology

ISSN: 1476-9433