Figure 1

Human and mouse FADD protein. Amino acids (AA) corresponding to the human FADD protein are marked in black, whereas AA corresponding to the mouse FADD protein are marked in grey. The death domain (DD) and death effector domain (DED) are essential for interaction with death receptors and transmission of the apoptotic signal. Human nuclear export sequence (NES in red) and nuclear localization sequence (NLS in blue) determine localization of the protein in the cytoplasm and the nucleus, which are associated with cell death and survival functions of the FADD protein, respectively. Human Ser 194 and mouse Ser 191 phosphorylation site (in purple) have a crucial role in survival/proliferation and cell cycle progression.