Figure 3

Structural basis of APL design. Crystal structure of N15 TCR-VSV8/K^b (left panel) [57]. The figure was rendered in MOLSCRIPT [58]. The TCR β chain is shown in gold, the TCR α chain in blue, K^b in magenta and β2M in red. Note the VSV8 peptide in green with the arrow pointing to the p4 valine side chain. Space-filling models of K^b in complex with VSV8 peptide and with its L4 variant (right panel) [31]. The K^b is shown as a GRASP surface [59] in magenta with peptide in CPK format and p4 residue atoms in green.